Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crystal structure of human Taspase1, a crucial protease regulating the function of MLL.

Structure (London, England : 1993) - 1 Oct 2005

Khan Javed A, Dunn Ben M, Tong Liang

Abstract excerpt

Taspase1 catalyzes the proteolytic processing of the mixed lineage leukemia (MLL) nuclear protein, which is required for maintaining Hox gene expression patterns. Chromosomal translocations of the MLL gene are associated with leukemia in infants. Taspase1, a threonine aspartase, is a member of the type 2 asparaginase family, but is the only protease in this family. We report here the crystal structures of human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorides
Share to Endopeptidases
Share to Enzyme Precursors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescent Dyes

Share to Histone-Lysine N-Methyltransferase

Share to Myeloid-Lymphoid Leukemia Protein

Share to Peptide Hydrolases

Share to Spectrum Analysis, Raman

Source

Identifiers

PMID: 16216576
DOI: 10.1016/j.str.2005.07.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crystal structure of human Taspase1, a crucial protease regulating the function of MLL.PMID 16216576Read ↗

New Structural Insights into the Function of the Catalytically Active Human Taspase1Semantic proximity Read ↗

Cell-based analysis of structure-function activity of threonine aspartase 1.Semantic proximity Read ↗

Overexpression of the catalytically impaired Taspase1 T234V or Taspase1 D233A variants does not have a dominant negative effect in T(4;11) leukemia cells.Semantic proximity Read ↗

Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis.Semantic proximity Read ↗

TASP1 is deleted in an infant with developmental delay, microcephaly, distinctive facial features, and multiple congenital anomalies.Semantic proximity Read ↗

Unravelling the Intricate Roles of FAM111A and FAM111B: From Protease-Mediated Cellular Processes to Disease Implications.Semantic proximity Read ↗

The Paracaspase MALT1.Semantic proximity Read ↗

MBTPS1: a membrane-bound transcription factor protease implicated in the pathogenesis of several skin and skeletal disordersSemantic proximity Read ↗

Structural evidence of functional divergence in human alkaline phosphatases.Semantic proximity Read ↗

Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates by cleaving TFIIA.Semantic proximity Read ↗

Type II Transmembrane Serine Protease (TTSP) deregulation in cancerSemantic proximity Read ↗

Protease propeptide structures, mechanisms of activation, and functions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.