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Article

Structural evidence of functional divergence in human alkaline phosphatases.

The Journal of biological chemistry - 20 Dec 2002

Le Du Marie-Hélène, Millan Jose Luis

Abstract excerpt

The evolution of the alkaline phosphatase (AP) gene family has lead to the existence in humans of one tissue-nonspecific (TNAP) and three tissue-specific isozymes, i.e. intestinal (IAP), germ cell (GCAP), and placental AP (PLAP). To define the structural differences between these isozymes, we have built models of the TNAP, IAP, and GCAP molecules based on the 1.8-structure of PLAP(1) and have performed a...

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Identifiers

PMID: 12372831
DOI: 10.1074/jbc.M207394200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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