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The structural basis of African swine fever virus pA104R binding to DNA and its inhibition by stilbene derivatives

1 May 2020

Abstract excerpt

African swine fever virus (ASFV) is a highly contagious nucleocytoplasmic large DNA virus (NCLDV) that causes nearly 100% mortality in swine. The development of effective vaccines and drugs against this virus is urgently needed. pA104R, an ASFV-derived histone-like protein, shares sequence and functional similarity with bacterial HU/IHF family members and is essential for viral replication. Herein, we solved the...

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PMID: 32358196
DOI: 10.1073/pnas.1922523117

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