Article
Small-Angle X-ray Scattering Models of APOBEC3B Catalytic Domain in a Complex with a Single-Stranded DNA Inhibitor.
Viruses - 12 Feb 2021
Barzak Fareeda M, Ryan Timothy M, Kvach Maksim V, Kurup Harikrishnan M, Aihara Hideki, Harris Reuben S, Filichev Vyacheslav V, Harjes Elena, Jameson Geoffrey B
Abstract excerpt
In normal cells APOBEC3 (A3A-A3H) enzymes as part of the innate immune system deaminate cytosine to uracil on single-stranded DNA (ssDNA) to scramble DNA in order to give protection against a range of exogenous retroviruses, DNA-based parasites, and endogenous retroelements. However, some viruses and cancer cells use these enzymes, especially A3A and A3B, to escape the adaptive immune response and thereby lead to...
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