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Functional Analysis of Human Hematopoietic Stem Cell Gene Expression Using Zebrafish

28 Jun 2005

Abstract excerpt

Although several reports have characterized the hematopoietic stem cell (HSC) transcriptome, the roles of HSC-specific genes in hematopoiesis remain elusive. To identify candidate regulators of HSC fate decisions, we compared the transcriptome of human umbilical cord blood and bone marrow (CD34+)(CD33-)(CD38-)Rho(lo)(c-kit+) cells, enriched for hematopoietic stem/progenitor cells with (CD34+)(CD33-)(CD38-)Rho(hi)...

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PMID: 16089502
DOI: 10.1371/journal.pbio.0030254

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