Article
Microsatellite polymorphism in the heme oxygenase-1 gene promoter and cardiac allograft vasculopathy.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Oct 2005
Ullrich Robert, Exner Markus, Schillinger Martin, Zuckermann Andreas, Raith Marianne, Dunkler Daniela, Horvat Reinhard, Grimm Michael, Wagner Oswald
Abstract excerpt
BACKGROUND: The heme oxygenase-1 (HO-1) isoenzyme has recently been suggested to protect transplants from ischemia-reperfusion and immunologic injury. Inducibility of this enzyme is modulated by a (GT)n dinucleotide length polymorphism in the HO-1 gene promoter. Short (class S) repeats are associated with greater up-regulation of HO-1 than are long repeats. In the present study, we investigated the impact of the...
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