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Enhancing the Anticancer Efficacy of Immunotherapy through Combination with Histone Modification Inhibitors

14 Dec 2018

Abstract excerpt

In the nucleus of each cell, the DNA is wrapped around histone octamers, forming the so-called "nucleosomal core particles". The histones undergo various modifications that influence chromatin structure and function, including methylation, acetylation, ubiquitination, phosphorylation, and SUMOylation. These modifications, known as epigenetic modifications (defined as heritable molecular determinants of phenotype...

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PMID: 30558227
DOI: 10.3390/genes9120633

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