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Article

Genetic Modifiers of Liver Disease in Cystic Fibrosis

8 Sept 2009

Abstract excerpt

CONTEXT: A subset (approximately 3%-5%) of patients with cystic fibrosis (CF) develops severe liver disease with portal hypertension. OBJECTIVE: To assess whether any of 9 polymorphisms in 5 candidate genes (alpha(1)-antitrypsin or alpha(1)-antiprotease [SERPINA1], angiotensin-converting enzyme [ACE], glutathione S-transferase [GSTP1], mannose-binding lectin 2 [MBL2], and transforming growth factor beta1 [TGFB1])...

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PMID: 19738092
DOI: 10.1001/jama.2009.1295

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