Article
Disease modifying genes in cystic fibrosis.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Aug 2005
Slieker Martijn G, Sanders Elisabeth A M, Rijkers Ger T, Ruven Henk J T, van der Ent Cornelis K
Abstract excerpt
The variation in cystic fibrosis (CF) lung disease and development of CF related complications correlates poorly with the genotype of the CF transmembrane regulator (CFTR) and with environmental factors. Increasing evidence suggests that phenotypic variation in CF can be attributed to genetic variation in genes other than the CFTR gene, so-called modifier genes. In recent years, multiple candidate modifier genes...
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