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Article

Whole genome linkage scan of recurrent depressive disorder from the depression network study.

Human molecular genetics - 15 Nov 2005

McGuffin Peter, Knight Jo, Breen Gerome, Brewster Shyama, Boyd Peter R, Craddock Nick, Gill Mike, Korszun Ania, Maier Wolfgang, Middleton Lefkos, Mors Ole, Owen Michael J, Perry Julia, Preisig Martin, Reich Theodore, Rice John, Rietschel Marcella, Jones Lisa, Sham Pak, Farmer Anne E

Abstract excerpt

Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for female-female pairs exceeded 3 (but reduced to 2.73 when corrected for multiple testing). The region includes a gene, MTHFR, that in previous studies has been associated with depressive symptoms. Two...

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Source

Identifiers

PMID: 16203746
DOI: 10.1093/hmg/ddi363

Genes

DAO
MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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