Article
Sequence diversity within the HA-1 gene as detected by melting temperature assay without oligonucleotide probes.
BMC medical genetics - 4 Oct 2005
Graziano Claudio, Giorgi Massimo, Malentacchi Cecilia, Mattiuz Pier Luigi, Porfirio Berardino
Abstract excerpt
BACKGROUND: The minor histocompatibility antigens (mHags) are self-peptides derived from common cellular proteins and presented by MHC class I and II molecules. Disparities in mHags are a potential risk for the development of graft-versus-host disease (GvHD) in the recipients of bone marrow from HLA-identical donors. Two alleles have been identified in the mHag HA-1. The correlation between mismatches of the mHag...
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