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Article

Emergence of young human genes after a burst of retroposition in primates.

PLoS biology - 1 Nov 2005

Marques Ana Claudia, Dupanloup Isabelle, Vinckenbosch Nicolas, Reymond Alexandre, Kaessmann Henrik

Abstract excerpt

The origin of new genes through gene duplication is fundamental to the evolution of lineage- or species-specific phenotypic traits. In this report, we estimate the number of functional retrogenes on the lineage leading to humans generated by the high rate of retroposition (retroduplication) in primates. Extensive comparative sequencing and expression studies coupled with evolutionary analyses and simulations...

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Identifiers

PMID: 16201836
DOI: 10.1371/journal.pbio.0030357
PMCID: PMC1251493

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