Article
Analysis of variable retroduplications in human populations suggests coupling of retrotransposition to cell division.
Genome research - 1 Dec 2013
Abyzov Alexej, Iskow Rebecca, Gokcumen Omer, Radke David W, Balasubramanian Suganthi, Pei Baikang, Habegger Lukas, Lee Charles, Gerstein Mark
Abstract excerpt
In primates and other animals, reverse transcription of mRNA followed by genomic integration creates retroduplications. Expressed retroduplications are either "retrogenes" coding for functioning proteins, or expressed "processed pseudogenes," which can function as noncoding RNAs. To date, little...
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