Article
Polymorphism of the interleukin-1 receptor antagonist gene: a factor in susceptibility to rheumatoid arthritis in a Spanish population.
Arthritis and rheumatism - 1 Oct 2005
Carreira Patricia E, Gonzalez-Crespo Maria R, Ciruelo Elena, Pablos Jose L, Santiago Begoña, Gomez-Camara Agustin, Gomez-Reino Juan J
Abstract excerpt
OBJECTIVE: To assess whether an interleukin-1 receptor antagonist gene (IL1RN) polymorphism is associated with disease susceptibility and/or severity in a Spanish population of patients with rheumatoid arthritis (RA). METHODS: An 86-bp variable-number tandem repeat polymorphism within IL1RN intron 2 was analyzed by polymerase chain reaction in genomic DNA obtained from 247 unrelated patients with RA (group A) and...
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