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Article

Monozygotic twins clinically discordant for scleroderma show concordance for fibroblast gene expression profiles

30 Sept 2005

Abstract excerpt

OBJECTIVE: Fewer than 5% of monozygotic (MZ) and dizygotic (DZ) twin pairs are clinically concordant for systemic sclerosis (SSc), yet the majority of MZ twins are concordant for antinuclear antibodies. To discover genetic versus nongenetic molecular pathways important to the pathogenesis of SSc, we compared global gene expression patterns in twins discordant for SSc. METHODS: Total RNA from dermal fibroblasts of...

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PMID: 16200604
DOI: 10.1002/art.21355

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