Article
Molecular subsets in the gene expression signatures of scleroderma skin.
PloS one - 16 Jul 2008
Milano Ausra, Pendergrass Sarah A, Sargent Jennifer L, George Lacy K, McCalmont Timothy H, Connolly M Kari, Whitfield Michael L
Abstract excerpt
BACKGROUND: Scleroderma is a clinically heterogeneous disease with a complex phenotype. The disease is characterized by vascular dysfunction, tissue fibrosis, internal organ dysfunction, and immune dysfunction resulting in autoantibody production. METHODOLOGY AND FINDINGS: We analyzed the genome-wide patterns of gene expression with DNA microarrays in skin biopsies from distinct scleroderma subsets including 17...
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