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Article

Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblasts.

Arthritis and rheumatism - 1 Jun 2006

Gardner Humphrey, Shearstone Jeffrey R, Bandaru Raj, Crowell Tom, Lynes Matthew, Trojanowska Maria, Pannu Jaspreet, Smith Edwin, Jablonska Stefania, Blaszczyk Maria, Tan Filemon K, Mayes Maureen D

Abstract excerpt

OBJECTIVE: To determine whether biopsy specimens obtained from systemic sclerosis (SSc) lesions show a distinctive gene profile, whether that gene profile is maintained in fibroblasts cultured from SSc skin biopsy specimens, and whether results from tissue obtained from multiple clinical centers can be combined to yield useful observations in this rare disease. METHODS: Biopsy samples and passaged fibroblasts...

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Identifiers

PMID: 16736506
DOI: 10.1002/art.21894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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