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Article

Deficits in amygdaloid cAMP-responsive element-binding protein signaling play a role in genetic predisposition to anxiety and alcoholism.

The Journal of clinical investigation - 1 Oct 2005

Pandey Subhash C, Zhang Huaibo, Roy Adip, Xu Tiejun

Abstract excerpt

We investigated the role of cAMP-responsive element-binding protein (CREB) in genetic predisposition to anxiety and alcohol-drinking behaviors using alcohol-preferring (P) and -nonpreferring (NP) rats. The levels of CREB, phosphorylated CREB, and neuropeptide Y (NPY) were innately lower in the central amygdala (CeA) and medial amygdala (MeA), but not in the basolateral amygdala (BLA), of P rats compared with NP...

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Identifiers

PMID: 16200210
DOI: 10.1172/JCI24381
PMCID: PMC1236671

Genes

NPY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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