Article
Epidermal growth factor receptor gene mutation in non-small cell lung cancer using highly sensitive and fast TaqMan PCR assay.
Lung cancer (Amsterdam, Netherlands) - 1 Dec 2005
Endo Katsuhiko, Konishi Akimitsu, Sasaki Hidefumi, Takada Minoru, Tanaka Hisaichi, Okumura Meinoshin, Kawahara Masaaki, Sugiura Hironori, Kuwabara Yoshiyuki, Fukai Ichiro, Matsumura Akihide, Yano Motoki, Kobayashi Yoshihiro, Mizuno Kotaro, Haneda Hiroshi, Suzuki Eriko, Iuchi Keiji, Fujii Yoshitaka
Abstract excerpt
Epidermal growth factor receptor (EGFR) gene mutations have been found in a subset of non-small cell lung cancer (NSCLC) with good clinical response to gefitinib therapy. A quick and sensitive method with large throughput is required to utilize the information to determine whether the molecular targeted therapy should be applied for the particular NSCLC patients. Using probes for the 13 different mutations...
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