Article
A common interleukin-6 promoter polymorphism in patients with vulvar cancer.
Journal of the Society for Gynecologic Investigation - 1 Dec 2005
Grimm Christoph, Six Lucia, Tomovski Caroline, Speiser Paul, Joura Elmar, Zeillinger Robert, Sliutz Gerhard, Reinthaller Alexander, Hefler Lukas A
Abstract excerpt
OBJECTIVE: Besides its important role in immune response and inflammatory processes the cytokine interleukin-6 (IL-6) is crucially involved in carcinogenesis. A common polymorphism within the gene encoding IL-6 (IL6) is known to alter IL-6 protein expression and has been associated with patients' prognosis in various malignancies. No data are available with respect to vulvar cancer. Therefore, we determined the...
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