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Article

Association of interleukin-6 (-174G>C) promoter polymorphism with risk of squamous cell esophageal cancer and tumor location: an exploratory study.

Clinical immunology (Orlando, Fla.) - 1 Aug 2008

Upadhyay Rohit, Jain Meenu, Kumar Shaleen, Ghoshal Uday Chand, Mittal Balraj

Abstract excerpt

Chronic inflammation plays a role in transformation from normal cell to malignant state. Interleukin-6 (IL-6) regulates inflammation and various physiological processes. IL-6 promoter polymorphism (-174G>C) is associated with transcription differences in vitro and in vivo. High expression of IL-6 may result in oxidative DNA damage and enhance risk of carcinogenesis. Therefore, we aimed to evaluate association of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18502691
DOI: 10.1016/j.clim.2008.03.519

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