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Article

Epidermal growth factor receptor mutations are associated with gefitinib sensitivity in non-small cell lung cancer in Japanese.

Lung cancer (Amsterdam, Netherlands) - 1 Jan 2006

Uramoto Hidetaka, Sugio Kenji, Oyama Tsunehiro, Ono Kenji, Sugaya Masakazu, Yoshimatsu Takashi, Hanagiri Takeshi, Morita Masaru, Yasumoto Kosei

Abstract excerpt

The protein-kinase family is the most frequently mutated gene family found in human cancer. Gefitinib, an ATP-competitive inhibitor of epidermal growth factor receptor (EGFR), also appears to be particularly effective in adenocarcinoma of the lung and in patients without smoking history. To determine whether lung tumors sensitive to gefitinib contained mutations within the tyrosine kinase (TK) domain of EGFR, we...

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Identifiers

PMID: 16198442
DOI: 10.1016/j.lungcan.2005.08.006

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Epidermal growth factor receptor mutations are associated with gefitinib sensitivity in non-small cell lung cancer in Japanese.PMID 16198442Read ↗

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