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Article

IL-10 mediates resistance to adoptive transfer experimental autoimmune encephalomyelitis in MyD88(-/-) mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2010

Cohen Shmuel J, Cohen Irun R, Nussbaum Gabriel

Abstract excerpt

MyD88 is an adaptor molecule that functions in the innate signaling induced by proinflammatory adjuvants that interact with TLRs. Mice lacking MyD88, for example, resist active experimental autoimmune encephalomyelitis (EAE) induced by immunization with an encephalitogenic myelin oligodendrocyte glycoprotein (MOG) peptide in CFA. We reasoned that MyD88(-/-) mice, nevertheless, should be susceptible to EAE...

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Topics

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Share to Adoptive Transfer
Share to Autoimmunity
Share to Encephalomyelitis, Autoimmune, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myelin-Associated Glycoprotein

Share to Myelin-Oligodendrocyte Glycoprotein

Share to Myelin Proteins

Share to Myeloid Differentiation Factor 88

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Source

Identifiers

PMID: 19949074
DOI: 10.4049/jimmunol.0900296

Genes

MOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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