Article
Molecular genetics of human glioma.
Current opinion in oncology - 1 May 1995
Westermark B, Nistér M
Abstract excerpt
This review focuses on genes that have a proven or presumed role in the genesis of astrocytic tumors. A common theme in glioblastoma is the amplification of genes that code for growth factor receptors of the protein-tyrosine kinase family (epidermal growth factor receptor, platelet-derived growth factor receptor-alpha, met). The majority of glioblastomas also have alterations in genes that encode factors that are...
Topics
- Animals
- Brain Neoplasms
- Gene Amplification
- Gene Deletion
- Genes, Tumor Suppressor
- Glioma
- Humans
- Mutation