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Article

Effects of a metabotropic, mglu5, glutamate receptor antagonist on ethanol consumption by genetic drinking rats.

Alcohol and alcoholism (Oxford, Oxfordshire) - 1 Jan 2000

McMillen Brian A, Crawford Monica S, Kulers Cortney M, Williams Helen L

Abstract excerpt

AIMS: To compare the effect of an antagonist of the mGlu5 glutamate receptor, 2-methyl-6-(phenylethynyl)pyridine (MPEP) on a test for anxiety and on the volitional consumption of ethanol. METHODS: The test for anxiety was placement of a Sprague-Dawley rat for a 5 min observation period in an elevated plus-maze. Volitional consumption of ethanol in a two-choice paradigm was determined for male and female myers...

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PMID: 16186143
DOI: 10.1093/alcalc/agh200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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