Article
Regulatory mutations in human lipoprotein disorders and atherosclerosis.
Current opinion in lipidology - 1 Apr 1996
Kontula K, Ehnholm C
Abstract excerpt
Most known mutations underlying human lipoprotein abnormalities affect the protein coding sequence of the gene involved. Mutations in the regulatory regions-promoters, enhancers, binding sites for transcription factors and other elements-may markedly alter the transcription efficiency of lipid-re...
Topics
- Apolipoprotein C-III
- Apolipoproteins C
- Arteriosclerosis
- Genes, Regulator
- Humans
- Hypercholesterolemia
- Lipoprotein Lipase
- Lipoproteins
- Mutation
- Promoter Regions, Genetic