Article
Ten allelic apolipoprotein[a] 5' flanking fragments exhibit comparable promoter activities in HepG2 cells.
Journal of lipid research - 1 Aug 1995
Bopp S, Köchl S, Acquati F, Magnaghi P, Pethö-Schramm A, Kraft H G, Utermann G, Müller H J, Taramelli R
Abstract excerpt
Plasma levels of the atherogenic lipoprotein[a] represent a quantitative genetic trait that is primarily controlled by the polymorphic apolipoprotein[a] locus on chromosome 6q. The more than 1000-fold variation in lipoprotein[a] plasma levels is explained to a large extent by a remarkable size po...
Topics
- Alleles
- Apolipoproteins A
- Base Sequence
- Cloning, Molecular
- Electrophoresis, Gel, Pulsed-Field
- Gene Expression Regulation
- Genes, Reporter
- Genetic Variation
- Heterozygote
- Humans
- Immunoblotting
- Liver
- Molecular Sequence Data
- Promoter Regions, Genetic
- Sequence Analysis, DNA
- Transfection
- Tumor Cells, Cultured