Article
Polymorphism in the human apolipoprotein A-I gene promoter region. Association of the minor allele with decreased production rate in vivo and promoter activity in vitro.
The Journal of clinical investigation - 1 Jun 1992
Smith J D, Brinton E A, Breslow J L
Abstract excerpt
We investigated a common polymorphism in the human apolipoprotein A-I gene promoter at a position 76 bp upstream of the transcriptional start site. 54 human subjects, whose apoAI production rates had been determined by apoAI turnover studies, were genotyped at this polymorphic position by a novel...
Topics
- Alleles
- Apolipoprotein A-I
- Base Sequence
- Cholesterol, HDL
- DNA
- Female
- Genotype
- Humans
- Kinetics
- Male
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Promoter Regions, Genetic