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[Study on expression of PS1 in APP-PS1 double gene stably transfected cell lines and its relation to gamma-secretase].

Zhonghua bing li xue za zhi = Chinese journal of pathology - 1 May 2005

Liang Ping, Pan Yang-xing, Zhao Xue-mei, Du Hong-zhen, Zhang Ji-min

Abstract excerpt

OBJECTIVE: To study the role of presenilin1 (PS1) in the processing of beta-amyloid precursor protein (APP) to amyloid beta-peptide (Abeta) and its relation to gamma-secretase in the pathogenesis of Alzheimer's disease (AD). METHODS: Several CHO cell lines stably transfected with either wide-type or mutant PS1 (M(146)L) along with APP(751) genes were established. The expression of PS1 and its half-life were...

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PMID: 16181553

Genes

APP

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