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Article

Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease.

Journal of neurochemistry - 1 Dec 1997

Ancolio K, Marambaud P, Dauch P, Checler F

Abstract excerpt

Recent reports indicate that missense mutations on presenilin (PS) 1 are likely responsible for the main early-onset familial forms of Alzheimer's disease (FAD). Consensual data obtained through distinct histopathological, cell biology, and molecular biology approaches have led to the conclusion...

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Source

Identifiers

PMID: 9375682
DOI: 10.1046/j.1471-4159.1997.69062494.x

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9375682-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease.PMID 9375682Read ↗

Monogenic determinants of familial Alzheimer's disease: presenilin-1 mutations.Semantic proximity Read ↗

Loss of presenilin function is associated with a selective gain of APP functionSemantic proximity Read ↗

Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.Semantic proximity Read ↗

Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.Semantic proximity Read ↗

Familial Alzheimer Disease-linked Presenilin 1 Variants Enhance Production of Both Aβ1–40 and Aβ1–42 Peptides That Are Only Partially Sensitive to a Potent Aspartyl Protease Transition State Inhibitor of “γ-Secretase”Semantic proximity Read ↗

Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds.Semantic proximity Read ↗

Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease.Semantic proximity Read ↗

Wild-type presenilin 1 protects against Alzheimer disease mutation-induced amyloid pathology.Semantic proximity Read ↗

Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase.Semantic proximity Read ↗

Identification of the role of presenilins beyond Alzheimer's disease.Semantic proximity Read ↗

Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ.Semantic proximity Read ↗

Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage.Semantic proximity Read ↗

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