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Article

Implications of presenilin 1 mutations in Alzheimer's disease.

Mechanisms of ageing and development - 15 Mar 1999

Komano H, Sudoh S, Kawamura Y, Wang R, Yanagisawa K

Abstract excerpt

Mutations in presenilin 1 (PS1) and presenilin 2 (PS2) are the most common genetic factors underlying the development of early-onset familial Alzheimer's disease (FAD). To investigate the pathogenic mechanism of PS1 mutations linked to FAD, we established inducible mouse neuroblastoma (Neuro 2a) cell lines expressing the human wild-type (wt) or mutated PS1(M146L or deltaexon 10) under the control of the Lac...

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PMID: 10360683
DOI: 10.1016/s0047-6374(98)00135-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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