Article
A functional macrophage migration inhibitory factor promoter polymorphism is associated with reduced diffusing capacity.
American journal of physiology. Lung cellular and molecular physiology - 1 Feb 2019
Zhang C, Ramsey C, Berical A, Yu L, Leng L, McGinnis K A, Song Y, Michael H, McCormack M C, Allore H, Morris A, Crothers K, Bucala R, Lee P J, Sauler M
Abstract excerpt
Cigarette smoke exposure is the leading modifiable risk factor for chronic obstructive pulmonary disease (COPD); however, the clinical and pathologic consequences of chronic cigarette smoke exposure are variable among smokers. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine implicated in the pathogenesis of COPD. Within the promoter of the MIF gene is a functional polymorphism that...
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