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Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia

23 Sept 2005

Abstract excerpt

In chronic lymphocytic leukemia (CLL), chromosomes usually evade detailed cytogenetic analyses because cells poorly respond to the traditionally used set of mitogens. We applied novel technologies, such as stimulation of CLL cells either with CD40 ligand or with a combination of CpG-oligodeoxynucleotides and IL-2, to increase the frequency of metaphase spreads for detailed chromosome analysis in 96 patients with...

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PMID: 16179374
DOI: 10.1182/blood-2005-05-2093

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