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Article

Prognostic significance of translocations in the presence of mutated IGHV and of cytogenetic complexity at diagnosis of chronic lymphocytic leukemia.

Haematologica - 1 Jun 2021

Heerema Nyla A, Muthusamy Natarajan, Zhao Qiuhong, Ruppert Amy S, Breidenbach Heather, Andritsos Leslie A, Grever Michael R, Maddocks Kami J, Woyach Jennifer, Awan Farrukh, Long Meixiao, Gordon Amber, Coombes Caitlin, Byrd John C

Abstract excerpt

Mutations of the IGH variable region in patients with chronic lymphocytic leukemia (CLL) are associated with a favorable prognosis. Cytogenetic complexity (>3 unrelated aberrations) and translocations have been associated with an unfavorable prognosis. While mutational status of IGHV is stable, cytogenetic aberrations frequently evolve. However, the relationships of these features as prognosticators at diagnosis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32414849
DOI: 10.3324/haematol.2018.212571
PMCID: PMC8168513

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