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CD40L stimulation enhances the ability of conventional metaphase cytogenetics to detect chromosome aberrations in B‐cell chronic lymphocytic leukaemia cells

29 Aug 2002

Abstract excerpt

Conventional metaphase cytogenetics underestimates the frequency of specific chromosome aberrations in B-cell chronic lymphocytic leukaemia (B-CLL) as a result of the very low proliferative activity of these cells in vitro. New molecular approaches, such as fluorescence in situ hybridization (FISH) or comparative genomic hybridization (CGH), may circumvent this problem, at least in part, but these techniques are...

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PMID: 12199774
DOI: 10.1046/j.1365-2141.2002.03719.x

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