Different genotype distribution of the GNB3 C825T polymorphism of the G protein beta3 subunit in adenomas and differentiated thyroid carcinomas of follicular cell origin.

Abstract excerpt

A C825T polymorphism has been demonstrated in the GNB3 gene that encodes the Gbeta3 subunit of heterotrimeric G proteins. Due to enhanced G protein activation, the GNB3 825T allele is associated with an increased signal transduction activity. To elucidate a possible role in the development and course of thyroid tumours of follicular cell origin, C825T polymorphism genotypes and allele frequencies were...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adenoma
• Share to Aged, 80 and over