Common variants in the G protein beta3 subunit gene and thyroid disorders in a formerly iodine-deficient population.

doi:10.1089/thy.2009.0134

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Article

Common variants in the G protein beta3 subunit gene and thyroid disorders in a formerly iodine-deficient population.

Thyroid : official journal of the American Thyroid Association - 1 Oct 2009

Völzke Henry, Bornhorst Alexa, Rimmbach Christian, Petersenn Holger, Geissler Ingrid, Nauck Matthias, Wallaschofski Henri, Kroemer Heyo K, Rosskopf Dieter

Abstract excerpt

BACKGROUND: Heterotrimeric G proteins are key mediators of signals from membrane receptors-including the thyroid-stimulating hormone (TSH) receptor-to cellular effectors. Gain-of-function mutations in the TSH receptor and the Galpha(S) subunit occur frequently in hyperfunctioning thyroid nodules and differentiated thyroid carcinomas, whereby the T allele of a common polymorphism (825C>T, rs5443) in the G protein...

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Identifiers

PMID: 19772422
DOI: 10.1089/thy.2009.0134

Genes

GNB3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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