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Article

Delineation of the pH-Responsive Regulon Controlled by the Helicobacter pylori ArsRS Two-Component System.

Infection and immunity - 17 Mar 2021

Loh John T, Shum Miranda V, Jossart Scott D R, Campbell Anne M, Sawhney Neha, McDonald W Hayes, Scholz Matthew B, McClain Mark S, Forsyth Mark H, Cover Timothy L

Abstract excerpt

Helicobacter pylori encounters a wide range of pH within the human stomach. In a comparison of H. pylori cultured in vitro under neutral or acidic conditions, about 15% of genes are differentially expressed, and corresponding changes are detectable for many of the encoded proteins. The ArsRS two-component system (TCS), comprised of the sensor kinase ArsS and its cognate response regulator ArsR, has an important...

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PMID: 33526561
DOI: 10.1128/IAI.00597-20
PMCID: PMC8090972

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