Article
Nickel Represses the Synthesis of the Nickel Permease NixA ofHelicobacter pylori
1 Feb 2006
Abstract excerpt
Nickel acquisition is necessary for urease activity, a major virulence factor of the human gastric pathogen Helicobacter pylori. NixA was identified as a specific nickel uptake system in this organism. Addition of small amounts of nickel to media strongly stimulates urea hydrolysis. On the other hand, high nickel concentrations are deleterious to cell growth. As a possible protective reaction, nickel uptake seems...
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