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Article

Tissue- and sex-specific effects of β-carotene 15,15' oxygenase (BCO1) on retinoid and lipid metabolism in adult and developing mice.

Archives of biochemistry and biophysics - 15 Apr 2015

Kim Youn-Kyung, Zuccaro Michael V, Costabile Brianna K, Rodas Rebeka, Quadro Loredana

Abstract excerpt

In mammals, β-carotene-15,15'-oxygenase (BCO1) is the main enzyme that cleaves β-carotene, the most abundant vitamin A precursor, to generate retinoids (vitamin A derivatives), both in adult and developing tissues. We previously reported that, in addition to this function, BCO1 can also influence the synthesis of retinyl esters, the storage form of retinoids, in the mouse embryo at mid-gestation. Indeed, lack of...

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Identifiers

PMID: 25602705
DOI: 10.1016/j.abb.2015.01.002
PMCID: PMC4402122

Genes

BCO1
LRAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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