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Article

Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms.

Parasitology international - 1 Mar 2006

Sariego Idalia, Annoura Takeshi, Nara Takeshi, Hashimoto Muneaki, Tsubouchi Akiko, Iizumi Kyoichi, Makiuchi Takashi, Murata Eri, Kita Kiyoshi, Aoki Takashi

Abstract excerpt

Dihydroorotate dehydrogenase (DHOD) is the fourth enzyme in the de novo pyrimidine biosynthetic pathway and is essential in Trypanosoma cruzi, the parasitic protist causing Chagas' disease. T. cruzi and human DHOD have different biochemical properties, including the electron acceptor capacities and cellular localization, suggesting that T. cruzi DHOD may be a potential chemotherapeutic target against Chagas'...

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PMID: 16172019
DOI: 10.1016/j.parint.2005.08.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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