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Article

A yeast-based assay reveals a functional defect of the Q488H polymorphism in human Hsp90alpha.

Biochemical and biophysical research communications - 11 Nov 2005

MacLean Morag J, Llordella Marc Martínez, Bot Nathalie, Picard Didier

Abstract excerpt

It has been argued that the molecular chaperone Hsp90 guards the organism against genetic variations by stabilizing variant Hsp90 substrate proteins. However, little is known about polymorphisms affecting its own functions. We have followed up on a recent study describing two polymorphisms that alter the amino acid sequences of the two Hsp90 isoforms Hsp90alpha and Hsp90beta. Hsp90 is essential for cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16171778
DOI: 10.1016/j.bbrc.2005.09.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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