Functional analysis of a conserved amino-terminal region of HSP70 by site-directed mutagenesis.

doi:10.1002/yea.320070706

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Article

Functional analysis of a conserved amino-terminal region of HSP70 by site-directed mutagenesis.

Yeast (Chichester, England) - 1 Oct 1991

Nicolet C M, Craig E A

Abstract excerpt

Hsp70 proteins have been highly conserved throughout evolution. As a first step in a structure-function analysis of hsp70, we constructed and analysed the consequences of mutations in a portion of the SSA1 gene, a member of the Saccharomyces cerevisiae HSP70 multigene family, that encodes a nearl...

Topics

Adenosine Triphosphate
Amino Acid Sequence
Base Sequence
Fungal Proteins
Genes, Fungal
Genetic Complementation Test
Heat-Shock Proteins
Molecular Sequence Data
Multigene Family
Mutagenesis, Site-Directed
Oligopeptides
Phenotype
Phosphorylation
Saccharomyces cerevisiae
Temperature

Source

Open in PubMed

Identifiers

PMID: 1776361
DOI: 10.1002/yea.320070706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1776361-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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