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Article

Single nucleotide polymorphism that accompanies a missense mutation (Gln488His) impedes the dimerization of Hsp90.

The protein journal - 1 Jan 2009

Kobayakawa Takeshi, Yamada Shin-Ichi, Mizuno Akio, Ohara-Nemoto Yuko, Baba Tomomi T, Nemoto Takayuki K

Abstract excerpt

A single nucleotide polymorphism (SNP) that causes a missense mutation of highly conserved Gln488 to His of the alpha isoform of the 90-kDa heat shock protein (Hsp90alpha) molecular chaperone is observed in Caucasians. The mutated Hsp90alpha severely reduced the growth of yeast cells. To investigate this molecular mechanism, we examined the domain-domain interactions of human Hsp90alpha by using bacterial...

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Source

Identifiers

PMID: 19130193
DOI: 10.1007/s10930-008-9160-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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