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Article

Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53.

Oncogene - 19 Jan 2006

Zalcenstein A, Weisz L, Stambolsky P, Bar J, Rotter V, Oren M

Abstract excerpt

Tumor-associated mutant forms of p53 can exert an antiapoptotic gain of function activity, which confers a selective advantage upon tumor cells harboring such mutations. We report that mutant p53 suppresses the expression of the MSP (MST-1/HGFL) gene, encoding the ligand of the receptor tyrosine kinase RON, implicated in a variety of cellular responses. Mutant p53 associates with the MSP gene promoter and...

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Identifiers

PMID: 16170349
DOI: 10.1038/sj.onc.1209061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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