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Article

Kruppel-Like Factor 2 Is a Transcriptional Regulator of Chronic and Acute Inflammation

13 Mar 2013

Abstract excerpt

Although myeloid cell activation is requisite for an optimal innate immune response, this process must be tightly controlled to prevent collateral host tissue damage. Kruppel-like factor 2 (KLF2) is a potent regulator of myeloid cell proinflammatory activation. As an approximately 30% to 50% reduction in KLF2 levels has been observed in human subjects with acute or chronic inflammatory disorders, we studied the...

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PMID: 23499374
DOI: 10.1016/j.ajpath.2013.01.029

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