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Clinical significance and expression of cyclin kinase subunits 1 and 2 in hepatocellular carcinoma

21 Oct 2009

Abstract excerpt

BACKGROUND: The mammalian cyclin kinase subunit (Cks) family has two members, Cks1 and Cks2, which were identified based on the protein sequence homology to yeast Cks. Overexpression of Cks1 and Cks2 has been reported to be associated with high aggressiveness and a poor prognosis in various malignancies, including gastric, breast and prostate carcinomas. Yet, whether Cks1 and Cks2 are overexpressed in...

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PMID: 19845855
DOI: 10.1111/j.1478-3231.2009.02106.x

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