Article
Molecular approaches to prevention and therapy of aerodigestive tract cancers.
Journal of the National Cancer Institute. Monographs - 1 Jan 1992
Roth J A, Mukhopadhyay T, Tainsky M A, Fang K, Casson A G, Schneider P M
Abstract excerpt
We describe studies defining several molecular events in human non-small-cell lung cancer (NSCLC). These include increased growth factor and growth factor receptor expression and oncogene alterations. The epidermal growth factor receptor (EGFR) and erbB2 are expressed by NSCLC cells. Transforming growth factor-alpha (TGF-alpha) is produced by NSCLC and may mediate autocrine growth stimulation. Specific inhibition...
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