Article
Switching of vascular phenotypes within a murine breast cancer model induced by angiopoietin-2.
The Journal of pathology - 1 Mar 2009
Reiss Yvonne, Knedla Anette, Tal Andrea O, Schmidt M H H, Jugold Manfred, Kiessling Fabian, Burger Angelika M, Wolburg Hartwig, Deutsch Urban, Plate Karl H
Abstract excerpt
Sustained growth of solid tumours can rely on both the formation of new and the co-option of existing blood vessels. Current models suggest that binding of angiopoietin-2 (Ang-2) to its endothelial Tie2 receptor prevents receptor phosphorylation, destabilizes blood vessels, and promotes vascular permeability. In contrast, binding of angiopoietin-1 (Ang-1) induces Tie2 receptor activation and supports the...
Topics
- Angiopoietin-1
- Angiopoietin-2
- Animals
- Cell Line, Tumor
- Endothelial Cells
- Mammary Neoplasms, Experimental
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Neovascularization, Pathologic