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Article

Increased negative superhelical density in vivo enhances the genetic instability of triplet repeat sequences.

The Journal of biological chemistry - 11 Nov 2005

Napierala Marek, Bacolla Albino, Wells Robert D

Abstract excerpt

The influence of negative superhelical density on the genetic instabilities of long GAA.TTC, CGG.CCG, and CTG.CAG repeat sequences was studied in vivo in topologically constrained plasmids in Escherichia coli. These repeat tracts are involved in the etiologies of Friedreich ataxia, fragile X syndrome, and myotonic dystrophy type 1, respectively. The capacity of these DNA tracts to undergo deletions-expansions was...

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Source

Identifiers

PMID: 16166072
DOI: 10.1074/jbc.M508065200

Genes

GAA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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